The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2012
Filed:
Feb. 27, 2009
Peter A. Zahos, Harrington Park, NJ (US);
Anthony Calabro, Cleveland Heights, OH (US);
Aniq B. Darr, Piscataway, NJ (US);
Richard A. Gross, Plainview, NY (US);
Peter A. Zahos, Harrington Park, NJ (US);
Anthony Calabro, Cleveland Heights, OH (US);
Aniq B. Darr, Piscataway, NJ (US);
Richard A. Gross, Plainview, NY (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Abstract
A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided.