The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2012
Filed:
Aug. 05, 2008
Viktor S. Goldmakher, Newton, MA (US);
Robert J. Lutz, Wayland, MA (US);
Ravi V. J. Chari, Newton, MA (US);
Yelena V. Kovtun, Maynard, MA (US);
John M. Lambert, Cambridge, MA (US);
Rita Steeves, Stoneham, MA (US);
Hans K. Erickson, Cambridge, MA (US);
Viktor S. Goldmakher, Newton, MA (US);
Robert J. Lutz, Wayland, MA (US);
Ravi V. J. Chari, Newton, MA (US);
Yelena V. Kovtun, Maynard, MA (US);
John M. Lambert, Cambridge, MA (US);
Rita Steeves, Stoneham, MA (US);
Hans K. Erickson, Cambridge, MA (US);
Immunogen, Inc., Waltham, MA (US);
Abstract
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.