The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2012
Filed:
Dec. 14, 2007
Hyunil Lee, Daejeon, KR;
Hee Kyung Park, Daejeon, KR;
Bong Ho Um, Daejeon, KR;
Serka Kim, Daejeon, KR;
Jae Jin Choi, Daejeon, KR;
Jung Hyun Min, Daejeon, KR;
Hye Yeon Kim, Daejeon, KR;
Hyunil Lee, Daejeon, KR;
Hee Kyung Park, Daejeon, KR;
Bong Ho Um, Daejeon, KR;
Serka Kim, Daejeon, KR;
Jae Jin Choi, Daejeon, KR;
Jung Hyun Min, Daejeon, KR;
Hye Yeon Kim, Daejeon, KR;
Panagene Inc., , KR;
Abstract
The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.