The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2012
Filed:
Nov. 29, 2007
Hamed Aissaoui, Pulversheim, FR;
Christoph Boss, Allschwil, CH;
Markus Gude, Allschwil, CH;
Ralf Koberstein, Lorrach, DE;
Thierry Sifferlen, Wentzwiller, FR;
Hamed Aissaoui, Pulversheim, FR;
Christoph Boss, Allschwil, CH;
Markus Gude, Allschwil, CH;
Ralf Koberstein, Lorrach, DE;
Thierry Sifferlen, Wentzwiller, FR;
Actelion Pharmaceuticals Ltd., Allschwil, CH;
Abstract
The invention relates to piperidine compounds of formula (I): wherein X—Rrepresents —N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C)alkyl or halogen, or X—Rrepresents —NH—C(O)-heterocyclyl, wherein the heterocyclyl is selected from benzofuranyl and imidazo[2,1-b]-thiazolyl, wherein said heterocyclyl is unsubstituted or independently mono-, di- or tri-substituted wherein the substituents are independently selected from (C)alkyl; A represents a phenyl- or thiazolyl-group, wherein the phenyl or thiazolyl is unsubstituted or mono-substituted with (C)alkyl; B represents a phenyl-group, wherein the phenyl is unsubstituted or mono-, or di- substituted, wherein the substituents are independently selected from the group consisting of (C)alkyl, (C)alkoxy, trifluoromethyl, cyano and halogen; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.