The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2012
Filed:
Feb. 27, 2009
David Piper, Madison, WI (US);
Kurt Vogel, Madison, WI (US);
Mohammed Saleh Shekhani, Madison, WI (US);
Stephen Hess, Verona, WI (US);
Steve Duff, Middleton, WI (US);
Thomas Livelli, Madison, WI (US);
Zhong Zhong, Shanghai, CN;
David Piper, Madison, WI (US);
Kurt Vogel, Madison, WI (US);
Mohammed Saleh Shekhani, Madison, WI (US);
Stephen Hess, Verona, WI (US);
Steve Duff, Middleton, WI (US);
Thomas Livelli, Madison, WI (US);
Zhong Zhong, Shanghai, CN;
Life Technologies Corporation, Carlsbad, CA (US);
Abstract
Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG Kchannel, and the propensity of a test compound to influence that binding interaction.