The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2012
Filed:
Mar. 13, 2007
Jan Zur Megede, San Francisco, CA (US);
Susan Barnett, San Francisco, CA (US);
Ying Lian, Albany, CA (US);
Susan Engelbrecht, Tygerberg, ZA;
Estrelita Janse Van Rensburg, Tygerberg, ZA;
Thomas J. Scriba, Oxford, GB;
Jan zur Megede, San Francisco, CA (US);
Susan Barnett, San Francisco, CA (US);
Ying Lian, Albany, CA (US);
Susan Engelbrecht, Tygerberg, ZA;
Estrelita Janse van Rensburg, Tygerberg, ZA;
Thomas J. Scriba, Oxford, GB;
Novartis Vaccine & Diagnostics Inc, Emeryville, CA (US);
Abstract
The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.