The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2012
Filed:
Mar. 30, 2005
Francesca Levi-schaffer, Jerusalem, IL;
Ido Bachelet, Modiln, IL;
Ariel Munitz, Jerusalem, IL;
Lorenzo Moretta, Genoa, IT;
Alessandro Moretta, Genoa, IT;
Francesca Levi-Schaffer, Jerusalem, IL;
Ido Bachelet, Modiln, IL;
Ariel Munitz, Jerusalem, IL;
Lorenzo Moretta, Genoa, IT;
Alessandro Moretta, Genoa, IT;
Abstract
Disclosed are bi-specific complexes aimed at inhibiting mast cells, eosinophils and/or basophils, and thus, at inhibiting allergy-type reactions. In particular, said complexes are best exemplified by bi-specific antibodies, which bind to two targets present in the same cell. One target is the inhibitory receptor IRp60. The second target is a cell-specific activator, e.g. IgE, cKIT, FcεRI, IL5R or CCR3. Binding of the bi-specific antibody to its targets results in the induction of an inhibitory pathway, through the inhibition of the signaling from the activator. Compositions and uses of the bi-specific complexes are also described.