The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
Oct. 20, 2003
Marc Blondel, Saint-Pol de Leon, FR;
Christophe Cullin, Merignac, FR;
Jean Michel Vierfond, Maisons Alfort, FR;
Stephane Bach, Saint-Pol de Leon, FR;
Nicolas Talarek, Talence, FR;
Yvette Mettey, Poitiers, FR;
Marc Blondel, Saint-Pol de Leon, FR;
Christophe Cullin, Merignac, FR;
Jean Michel Vierfond, Maisons Alfort, FR;
Stephane Bach, Saint-Pol de Leon, FR;
Nicolas Talarek, Talence, FR;
Yvette Mettey, Poitiers, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Universite Victor Segalen Bordeaux 2, Bordeaux, FR;
Universite de Poitiers, Poiters, FR;
Abstract
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates.