The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
Mar. 30, 2009
Mitsuyuki Shimada, Nara, JP;
Toshiki Murata, Nara, JP;
Kinji Fuchikami, Kyoto, JP;
Hideki Jishita, Kyoto, JP;
Naoki Omori, Kyoto, JP;
Issei Kato, Nara, JP;
Mami Miura, Nara, JP;
Klaus Urbahns, Hyogo, JP;
Florian Gantner, Osaka, JP;
Kevin Bacon, Hyogo, JP;
Mitsuyuki Shimada, Nara, JP;
Toshiki Murata, Nara, JP;
Kinji Fuchikami, Kyoto, JP;
Hideki Jishita, Kyoto, JP;
Naoki Omori, Kyoto, JP;
Issei Kato, Nara, JP;
Mami Miura, Nara, JP;
Klaus Urbahns, Hyogo, JP;
Florian Gantner, Osaka, JP;
Kevin Bacon, Hyogo, JP;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Abstract
The present invention relates to novel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-γ activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoimmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis. The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to PI3K activity in a human or animal subject.