The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
Dec. 13, 2006
Nobuo Machinaga, Edogawa-ku, JP;
Shin Iimura, Edogawa-ku, JP;
Yoshiyuki Yoneda, Edogawa-ku, JP;
Jun Chiba, Edogawa-ku, JP;
Fumihito Muro, Edogawa-ku, JP;
Hideko Hoh, Edogawa-ku, JP;
Atsushi Nakayama, Edogawa-ku, JP;
Nobuo Machinaga, Edogawa-ku, JP;
Shin Iimura, Edogawa-ku, JP;
Yoshiyuki Yoneda, Edogawa-ku, JP;
Jun Chiba, Edogawa-ku, JP;
Fumihito Muro, Edogawa-ku, JP;
Hideko Hoh, Edogawa-ku, JP;
Atsushi Nakayama, Edogawa-ku, JP;
Daiichi Sankyo Company, Limited, Tokyo, JP;
Abstract
There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally. A compound represented by the following formula (I): wherein Rrepresents a hydrogen atom or a C1-8 alkyl group; Rrepresents a hydrogen atom, a halogen atom, a C1-8 alkoxy group, or a benzyloxy group which may be substituted; Q represents a monocyclic or bicyclic nitrogen-containing heterocyclic group which may be substituted, and has a nitrogen atom as the bonding site; Y represents an oxygen atom or CH; W represents a bicyclic aromatic hydrocarbon ring group which may be substituted, or a bicyclic aromatic heterocyclic group which may be substituted; R, Rand Reach independently represent a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group; and Arepresents a nitrogen atom or C—R(wherein Rrepresents a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group),