The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
Sep. 22, 2010
Thomas J. Kelleher, Thousand Oaks, CA (US);
Jan-ji Lai, Westborough, MA (US);
Joseph P. Decourcey, Boston, MA (US);
Paul D. Lynch, Arlington, MA (US);
Maurizio Zenoni, Ferentino Frosinone, IT;
Auro R. Tagliani, Pavia, IT;
Thomas J. Kelleher, Thousand Oaks, CA (US);
Jan-Ji Lai, Westborough, MA (US);
Joseph P. DeCourcey, Boston, MA (US);
Paul D. Lynch, Arlington, MA (US);
Maurizio Zenoni, Ferentino Frosinone, IT;
Auro R. Tagliani, Pavia, IT;
Cubist Pharmaceuticals, Inc., Lexington, MA (US);
Abstract
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.