The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
May. 14, 2007
György Báthori, Budapest, HU;
Dóra Méhn, Szeged, HU;
Pál Ákos, Zalaegerszeg, HU;
Péter Krajcsi, Budapest, HU;
Lajos Szente, Budapest, HU;
Éva Fenyvesi, Budapest, HU;
Ágnes Telbisz, Budapest, HU;
Balázs Sarkadi, Budapest, HU;
András Váradi, Budapest, HU;
Szilvia Gedey, Szeged, HU;
Hristos Glavinas, Szeged, HU;
Emese Kis, Mezöberény, HU;
Tünde Nagy, Pécs, HU;
Attila Németh, Budapest, HU;
Éva Molnár, Szeged, HU;
György Báthori, Budapest, HU;
Dóra Méhn, Szeged, HU;
Pál Ákos, Zalaegerszeg, HU;
Péter Krajcsi, Budapest, HU;
Lajos Szente, Budapest, HU;
Éva Fenyvesi, Budapest, HU;
Ágnes Telbisz, Budapest, HU;
Balázs Sarkadi, Budapest, HU;
András Váradi, Budapest, HU;
Szilvia Gedey, Szeged, HU;
Hristos Glavinas, Szeged, HU;
Emese Kis, Mezöberény, HU;
Tünde Nagy, Pécs, HU;
Attila Németh, Budapest, HU;
Éva Molnár, Szeged, HU;
SOLVO Biotechnológial ZRT., Budaörs, HU;
Abstract
The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane.