The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
Nov. 14, 2006
Akio Suzumura, Aichi, JP;
Jinyan Wang, Aichi, JP;
Takashi Matsui, Kanagawa, JP;
Sadatoshi Sakuma, Kanagawa, JP;
Shin Miyakawa, Tokyo, JP;
Masatoshi Fujiwara, Tokyo, JP;
Yoshikazu Nakamura, Tokyo, JP;
Akio Suzumura, Aichi, JP;
Jinyan Wang, Aichi, JP;
Takashi Matsui, Kanagawa, JP;
Sadatoshi Sakuma, Kanagawa, JP;
Shin Miyakawa, Tokyo, JP;
Masatoshi Fujiwara, Tokyo, JP;
Yoshikazu Nakamura, Tokyo, JP;
Ribomic, Inc., Tokyo, JP;
Cellmid Limited, Sydney, AU;
Abstract
The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.