The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2012
Filed:
Feb. 04, 2011
Philip M. Potter, Memphis, TN (US);
Monika Weirdl, Memphis, TN (US);
Matthew R. Redinbo, Chapel Hill, NC (US);
Philip M. Potter, Memphis, TN (US);
Monika Weirdl, Memphis, TN (US);
Matthew R. Redinbo, Chapel Hill, NC (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
The University of North Carolina, Chapel Hill, NC (US);
Abstract
Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.