The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2012
Filed:
Nov. 14, 2006
Maher Albitar, Coto de Caza, CA (US);
Hagop Kantarjian, Bellaire, TX (US);
Francis Giles, Bellaire, TX (US);
Iman Jilani, Houston, TX (US);
Maher Albitar, Coto de Caza, CA (US);
Hagop Kantarjian, Bellaire, TX (US);
Francis Giles, Bellaire, TX (US);
Iman Jilani, Houston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Quest Diagnostics Incorporated, San Clemente, CA (US);
Abstract
The present invention concerns the detection of gene products resulting from chromosomal translocations, including fusion proteins comprising a first and second region. In particular, the fusion proteins are identified following subjecting a sample comprising the proteins to a bead comprising an antibody to a first region, followed by subjecting the bead-antibody-fusion complex to a second antibody directed against the second region, thereby detecting the fusion protein. In particular aspects, the invention is employed to provide prognosis for an individual with cancer, to identify suitability for a particular cancer therapy, and/or to monitor response of a patient to a therapy, for example.