The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2012
Filed:
Apr. 28, 2005
Young Min Kim, Youngin-si, KR;
Sung Min Bae, Seoul, KR;
Dae Jin Kim, Seoul, KR;
Dae Hae Song, Seoul, KR;
Chang Ki Lim, Suwon-si, KR;
SE Chang Kwon, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Young Min Kim, Youngin-si, KR;
Sung Min Bae, Seoul, KR;
Dae Jin Kim, Seoul, KR;
Dae Hae Song, Seoul, KR;
Chang Ki Lim, Suwon-si, KR;
Se Chang Kwon, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Hanmi Holdings Co., Ltd., Seoul, KR;
Abstract
Disclosed are an Fc fragment modified by a non-peptide polymer, a pharmaceutical composition comprising the Fc fragment modified by the non-peptide polymer as a carrier, a complex of the Fc fragment and a drug via a linker and a pharmaceutical composition comprising such a complex. The Fc fragment modified by a non-peptide peptide according to the present invention lacks immunogenicity and effector functions. Due to these properties, the Fc fragment maintains the in vivo activity of a drug conjugated thereto in high levels, remarkably increases the serum half-life of the drug, and remarkably reduces the risk of inducing immune responses.