The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2012
Filed:
Apr. 28, 2009
Thomas Arrhenius, Del Mar, CA (US);
MI Chen, San Diego, CA (US);
Jie Fei Cheng, Carlsbad, CA (US);
Yujin Huang, San Diego, CA (US);
Alex Michael Nadzan, Encinitas, CA (US);
Richard Julius Penuliar, San Diego, CA (US);
David Mark Wallace, San Diego, CA (US);
Lin Zhang, San Diego, CA (US);
Gary D. Lopaschuk, Edmonton, CA;
Jason R. Dyck, Sherwood Park, CA;
Thomas Arrhenius, Del Mar, CA (US);
Mi Chen, San Diego, CA (US);
Jie Fei Cheng, Carlsbad, CA (US);
Yujin Huang, San Diego, CA (US);
Alex Michael Nadzan, Encinitas, CA (US);
Richard Julius Penuliar, San Diego, CA (US);
David Mark Wallace, San Diego, CA (US);
Lin Zhang, San Diego, CA (US);
Gary D. Lopaschuk, Edmonton, CA;
Jason R. Dyck, Sherwood Park, CA;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.