The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2012
Filed:
Jul. 09, 2007
Daniel Romo, College Station, TX (US);
Sung Wook Cho, College Station, TX (US);
Jeffrey W. Smith, San Diego, CA (US);
Robyn D. Richardson, San Diego, CA (US);
Daniel Romo, College Station, TX (US);
Sung Wook Cho, College Station, TX (US);
Jeffrey W. Smith, San Diego, CA (US);
Robyn D. Richardson, San Diego, CA (US);
The Texas A&M University System, College Station, TX (US);
Abstract
Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.