The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2012
Filed:
May. 24, 2010
Mark James Batchelor, Cumnor Hill, GB;
David Bebbington, Pewsey, GB;
Guy W. Bemis, Arlington, MA (US);
Wolf Herman Fridman, Paris, FR;
Roger John Gillespie, Nr. Malmesbury, GB;
Julian M. C. Golec, Swindon, GB;
Yong Gu, Brookline, MA (US);
David J. Lauffer, Stow, MA (US);
David J. Livingston, Newtonville, MA (US);
Saroop Singh Matharu, Cricklade, GB;
Michael D. Mullican, Needham, MA (US);
Mark A. Murcko, Holliston, MA (US);
Robert Murdoch, Highworth, GB;
Philip Nyce, Milbury, MA (US);
Andrea L. C. Robidoux, Andover, MA (US);
Michael Su, Newton, MA (US);
M. Woods Wannamaker, Stow, MA (US);
Keith P. Wilson, Hopkinton, MA (US);
Robert E. Zelle, Stow, MA (US);
Mark James Batchelor, Cumnor Hill, GB;
David Bebbington, Pewsey, GB;
Guy W. Bemis, Arlington, MA (US);
Wolf Herman Fridman, Paris, FR;
Roger John Gillespie, Nr. Malmesbury, GB;
Julian M. C. Golec, Swindon, GB;
Yong Gu, Brookline, MA (US);
David J. Lauffer, Stow, MA (US);
David J. Livingston, Newtonville, MA (US);
Saroop Singh Matharu, Cricklade, GB;
Michael D. Mullican, Needham, MA (US);
Mark A. Murcko, Holliston, MA (US);
Robert Murdoch, Highworth, GB;
Philip Nyce, Milbury, MA (US);
Andrea L. C. Robidoux, Andover, MA (US);
Michael Su, Newton, MA (US);
M. Woods Wannamaker, Stow, MA (US);
Keith P. Wilson, Hopkinton, MA (US);
Robert E. Zelle, Stow, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing N-acylamino compounds.