The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2012
Filed:
Jan. 13, 2010
Richard Schwartz, Bethesda, MD (US);
John Michael Berry, Belmont, CA (US);
Ajit Subramanian, Berkeley, CA (US);
Xiao Shi, Cupertino, CA (US);
Richard Schwartz, Bethesda, MD (US);
John Michael Berry, Belmont, CA (US);
Ajit Subramanian, Berkeley, CA (US);
Xiao Shi, Cupertino, CA (US);
Medimmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.