The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2012
Filed:
May. 27, 2010
Michael D. Burkart, San Diego, CA (US);
Kristine Clarke, San Diego, CA (US);
Andrew C. Mercer, LaJolla, CA (US);
James J. Laclair, San Diego, CA (US);
Jordan Meier, LaJolla, CA (US);
Michael D. Burkart, San Diego, CA (US);
Kristine Clarke, San Diego, CA (US);
Andrew C. Mercer, LaJolla, CA (US);
James J. LaClair, San Diego, CA (US);
Jordan Meier, LaJolla, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Methods to generate analogs of coenzyme A in vivo are disclosed. The methods to generate analogs of coenzyme A in a cell comprise reacting pantetheine or a derivative thereof with a reporter to form labeled pantetheine or a derivative thereof, contacting the cell with the labeled pantetheine or derivative thereof such that the labeled pantetheine or derivative thereof enters the cell, phosphorylating the labeled pantetheine or derivative thereof to form phosphopantetheine or a derivative thereof, adenylating the labeled phosphopantetheine or derivative thereof to form a labeled dephosphoCoenzyme A or derivative thereof, and phosphorylating the 3'-hydroxyl of the labeled dephosphoCoenzyme A or derivative thereof to form a labeled coenzyme A analog or derivative thereof.