The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2012
Filed:
Oct. 05, 2005
Howard J. Federoff, Rochester, NY (US);
William J. Bowers, Webster, NY (US);
John G. Frelinger, Pittsford, NY (US);
Richard A. Willis, Denver, CO (US);
Thomas G. Evans, Davis, CA (US);
Stephen Dewhurst, Rochester, NY (US);
Khaled A. Tolba, Rochester, NY (US);
Joseph D. Rosenblatt, Ft. Lauderdale, FL (US);
Howard J. Federoff, Rochester, NY (US);
William J. Bowers, Webster, NY (US);
John G. Frelinger, Pittsford, NY (US);
Richard A. Willis, Denver, CO (US);
Thomas G. Evans, Davis, CA (US);
Stephen Dewhurst, Rochester, NY (US);
Khaled A. Tolba, Rochester, NY (US);
Joseph D. Rosenblatt, Ft. Lauderdale, FL (US);
University of Rochester, Rochester, NY (US);
Abstract
The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.