The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2012
Filed:
Aug. 03, 2007
Vincent Sandanayaka, Northboro, MA (US);
Jasbir Singh, Naperville, IL (US);
Lei Zhao, Naperville, IL (US);
Peng Yu, Lisle, IL (US);
Mark E. Gurney, Grand Rapids, MI (US);
Vincent Sandanayaka, Northboro, MA (US);
Jasbir Singh, Naperville, IL (US);
Lei Zhao, Naperville, IL (US);
Peng Yu, Lisle, IL (US);
Mark E. Gurney, Grand Rapids, MI (US);
Decode Genetics EHF., Reykjavik, IS;
Abstract
Two chemical genera of pyrazolylphenyl and pyrrolylphenyl derivatives are disclosed. They have the general formula: In these compounds ring (a) is a pyrazole or pyrrole; Q is selected from the group consisting of a direct bond, O, S, SO, SO, NR, CH, CF, and C(O); HET is a 4-7-membered saturated nitrogenous heterocycle; and taken together ZW is H or Z is (CH)in which one or two (CH) may optionally be replaced by —O—, —NR—, —SO—, —S(O)—, —C(═O)— or —C═O(NH)—; and W is hydrogen, acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, —COOalkyl, —CHO, heterocyclyl, substituted aryl or substituted heterocyclyl. The compounds are inhibitors of LTA4H (leukotriene A4 hydrolase). They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.