The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2012
Filed:
Sep. 12, 2006
Arvind Kumar Singla, Chandigarh, IN;
Javed Naim Agrewala, Chandigarh, IN;
Rakesh Mulraj Vohra, Chandigarh, IN;
Ravinder Singh Jolly, Chandigarh, IN;
Arvind Kumar Singla, Chandigarh, IN;
Javed Naim Agrewala, Chandigarh, IN;
Rakesh Mulraj Vohra, Chandigarh, IN;
Ravinder Singh Jolly, Chandigarh, IN;
Council of Science and Industrial Research, New Delhi, IN;
Abstract
The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4T cells, CD8T cells and B cells and in the production of IL-4 and IFN-γ and antibodies. The compound operates through a mechanism by downregulating the expression of activation marker CD28 and upregulating the immunosuppressive marker CTLA-4. Caerulomycin A has previously been isolated fromand found to have useful antifungal activity. Prior to the present invention however, this compound had not been determined to have immunomodulatory activity.