The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2012
Filed:
Dec. 29, 2010
John L. Wallace, Ancaster, CA;
Giuseppe Cirino, Naples, IT;
Giuseppe Caliendo, Naples, IT;
Anna Sparatore, Milan, IT;
Vincenzo Santagada, Cosenza, IT;
Stefano Fiorucci, Perugia, IT;
John L. Wallace, Ancaster, CA;
Giuseppe Cirino, Naples, IT;
Giuseppe Caliendo, Naples, IT;
Anna Sparatore, Milan, IT;
Vincenzo Santagada, Cosenza, IT;
Stefano Fiorucci, Perugia, IT;
Antibe Therapeutics Inc., Calgary, CA;
Abstract
The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.