The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2012
Filed:
Sep. 17, 2008
Cristina Abucay Tan Hehir, Niskayuna, NY (US);
Stephen Johnson Lomnes, Philadelphia, PA (US);
Kenneth Michael Fish, Clifton Park, NY (US);
Tiberiu Mircea Siclovan, Rexford, NY (US);
Michael Christopher Montalto, Albany, NY (US);
Tunchiao Hubert Lam, Clifton Park, NY (US);
Cristina Abucay Tan Hehir, Niskayuna, NY (US);
Stephen Johnson Lomnes, Philadelphia, PA (US);
Kenneth Michael Fish, Clifton Park, NY (US);
Tiberiu Mircea Siclovan, Rexford, NY (US);
Michael Christopher Montalto, Albany, NY (US);
Tunchiao Hubert Lam, Clifton Park, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.