The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2012
Filed:
Apr. 09, 2008
David R. Elmaleh, Newton, MA (US);
Choi Sungwoon, Sharon, MA (US);
Alan J. Fischman, Boston, MA (US);
David R. Elmaleh, Newton, MA (US);
Choi Sungwoon, Sharon, MA (US);
Alan J. Fischman, Boston, MA (US);
The General Hospital Corporation, Charlestown, MA (US);
Abstract
Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: wherein:n is an integer of 1 to 6; X, Y, Zand Zcan be the same or different and are hydrogen, halo, haloalkyl, alkyl, aryl, (C-C) alkoxy, N-alkyl, (C-C) acyloxy, N-alkylene, —SH, —SR, wherein R is from the same group as Rand Rand can be the same or different than Rand R, amino, nitro, cyano, hydroxy, C(═O)OR, —C(═O)NRR, NRR, or S(═O)Rwhereinis 1 or 2, and Rto Rare independently hydrogen or (C-C) alkyl;