The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2012
Filed:
Nov. 05, 2006
Applicants:
Naoyuki Shimomura, Tsukuba, JP;
Atsushi Kamada, Tsukuba, JP;
Mamoru Miyazawa, Kamisu, JP;
Koichi Ito, Tsukuba, JP;
Inventors:
Naoyuki Shimomura, Tsukuba, JP;
Atsushi Kamada, Tsukuba, JP;
Mamoru Miyazawa, Kamisu, JP;
Koichi Ito, Tsukuba, JP;
Assignee:
Eisai R&D Management Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 311/22 (2006.01);
U.S. Cl.
CPC ...
Abstract
It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.