The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2012
Filed:
Apr. 26, 2006
Gregory Stephanopoulos, Winchester, MA (US);
Hal S. Alper, Cambridge, MA (US);
Curt Fischer, Cambridge, MA (US);
Elke Nevoigt, Berlin, DE;
Gregory Stephanopoulos, Winchester, MA (US);
Hal S. Alper, Cambridge, MA (US);
Curt Fischer, Cambridge, MA (US);
Elke Nevoigt, Berlin, DE;
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of another in the library and cells comprising the same. Methods utilizing either the libraries or cells of this invention, in optimizing gene expression, protein expression, or optimized gene or protein delivery are described.