The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2012
Filed:
May. 08, 2007
Kazuma Tomizuka, Yokohama, JP;
Hitoshi Yoshida, Yokohama, JP;
Kazunori Hanaoka, Sagamihara, JP;
Mitsuo Oshimura, Yonago, JP;
Isao Ishida, Yokohama, JP;
Kazuma Tomizuka, Yokohama, JP;
Hitoshi Yoshida, Yokohama, JP;
Kazunori Hanaoka, Sagamihara, JP;
Mitsuo Oshimura, Yonago, JP;
Isao Ishida, Yokohama, JP;
Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;
Abstract
The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.