The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2012
Filed:
Mar. 17, 2005
Wilhelmus Everhardus Hennink, Waddinxveen, NL;
Cornelis Franciscus Van Nostrum, Vlijmen, NL;
Marinus Jacob Van Steenbergen, Ede, NL;
Osamu Soga, Ibaraki, JP;
Cristianne Johanna Ferdinand Rijcken, Utrecht, NL;
Wilhelmus Everhardus Hennink, Waddinxveen, NL;
Cornelis Franciscus Van Nostrum, Vlijmen, NL;
Marinus Jacob Van Steenbergen, Ede, NL;
Osamu Soga, Ibaraki, JP;
Cristianne Johanna Ferdinand Rijcken, Utrecht, NL;
Universiteit Utrecht, Utrecht, NL;
Abstract
The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly ploy (hydroxyalkyl (meth) acrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.