The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2012
Filed:
Nov. 30, 2007
Pierre Colas, Santec, FR;
Benoit DE Chassey, Lyons, FR;
Ivan Jacques Mikaelian, Lyons, FR;
Brian B. Rudkin, Lyons, FR;
Pierre Colas, Santec, FR;
Benoit de Chassey, Lyons, FR;
Ivan Jacques Mikaelian, Lyons, FR;
Brian B. Rudkin, Lyons, FR;
Ecole Normale Superieure de Lyon, Lyons, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Abstract
The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.