The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2012
Filed:
Apr. 30, 2008
Eric Meggers, Philadelphia, PA (US);
Peng Xie, Philadelphia, PA (US);
Douglas S. Williams, Philadelphia, PA (US);
Ronen Marmorstein, Swarthmore, PA (US);
Eric Meggers, Philadelphia, PA (US);
Peng Xie, Philadelphia, PA (US);
Douglas S. Williams, Philadelphia, PA (US);
Ronen Marmorstein, Swarthmore, PA (US);
The Trustees Of The University Of Pennsylvania, Philadelphia, PA (US);
The Wistar Institute Of Anatomy And Biology, Philadelphia, PA (US);
Abstract
Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.