The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2012
Filed:
Jan. 31, 2006
Ebo Sijbren Bos, Oss, NL;
Martin DE Kort, Oss, NL;
Meertinus Jan Smit, Oss, NL;
Constant Adriaan Anton Van Boeckel, Oss, NL;
Ebo Sijbren Bos, Oss, NL;
Martin De Kort, Oss, NL;
Meertinus Jan Smit, Oss, NL;
Constant Adriaan Anton Van Boeckel, Oss, NL;
N.V. Organon, Oss, NL;
Abstract
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being a synthetic sulfated oligosaccharide comprising 4-18 monosaccharide units and per se having affinity to antithrombin III and the spacer being a bond or an essentially pharmacologically inactive flexible linking residue, or a pharmaceutically acceptable salt thereof. The conjugates of the invention have improved pharmacokinetic properties when compared to the original polypeptides (i.e. the corresponding non-conjugated polypeptides per se).