The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2012
Filed:
Aug. 14, 2009
Sung Hwan Moon, Suwon-shi, KR;
Jae Uk Chung, Suwon-shi, KR;
Sung Chan Lee, Suwon-shi, KR;
Masakatsu Eguchi, Bellevue, WA (US);
Michael Kahn, Los Angeles, CA (US);
Kwang Won Jeong, Seoul, KR;
CU Nguyen, Pasadena, CA (US);
Sung Hwan Moon, Suwon-shi, KR;
Jae Uk Chung, Suwon-shi, KR;
Sung Chan Lee, Suwon-shi, KR;
Masakatsu Eguchi, Bellevue, WA (US);
Michael Kahn, Los Angeles, CA (US);
Kwang Won Jeong, Seoul, KR;
Cu Nguyen, Pasadena, CA (US);
Choongwae Pharma Corporation, Seoul, KR;
Abstract
Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.