The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2012
Filed:
Sep. 15, 2009
Taifo Mahmud, Corvallis, OR (US);
Zixin Deng, Shanghai, CN;
Linquan Bai, Shanghai, CN;
Hui Xu, Shanghai, CN;
Jongtae Yang, Corvallis, OR (US);
Taifo Mahmud, Corvallis, OR (US);
Zixin Deng, Shanghai, CN;
Linquan Bai, Shanghai, CN;
Hui Xu, Shanghai, CN;
Jongtae Yang, Corvallis, OR (US);
Abstract
This disclosure relates to validamycin A biosynthesis and in particular, to methods of producing validamycin A analogs and uses thereof. In a particular example, a method for making a validamycin A analog includes transforming a host cell with one or more recombinant DNA vectors to produce a valN-inactivated mutant; and culturing the valN-inactivated mutant in a culture medium to produce a validamycin A analog, such as 1,1'-bis-valienamine and validienamycin, and their conversion to valienamine. The present disclosure further relates to compositions including such compounds as well as methods of using the compositions, such as for antifungal agents.