The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2012
Filed:
Apr. 13, 2006
Gianni Chessari, Cambridge, GB;
Miles Stuart Congreve, Cambridge, GB;
Eva Figueroa Navarro, Cambridge, GB;
Martyn Frederickson, Cambridge, GB;
Christopher Murray, Cambridge, GB;
Alison Jo-anne Woolford, Cambridge, GB;
Maria Grazia Carr, Luton, GB;
Michael Alistair O'brien, Hitchin, GB;
Andrew James Woodhead, Cambridge, GB;
Robert Downham, Manchester, GB;
Theresa Rachel Phillips, Macclesfield, GB;
Gianni Chessari, Cambridge, GB;
Miles Stuart Congreve, Cambridge, GB;
Eva Figueroa Navarro, Cambridge, GB;
Martyn Frederickson, Cambridge, GB;
Christopher Murray, Cambridge, GB;
Alison Jo-Anne Woolford, Cambridge, GB;
Maria Grazia Carr, Luton, GB;
Michael Alistair O'Brien, Hitchin, GB;
Andrew James Woodhead, Cambridge, GB;
Robert Downham, Manchester, GB;
Theresa Rachel Phillips, Macclesfield, GB;
Astex Therapeutics, Ltd., Cambridge, GB;
Abstract
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein Ris hydrogen; Ris hydroxy or methoxy; Ris selected from hydrogen; halogen; cyano; optionally substituted Chydrocarbyl and optionally substituted Chydrocarbyloxy; Ris selected from hydrogen; a group —(O)—Rwhere n is 0 or 1 and Ris an optionally substituted acyclic Chydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-Chydrocarbyl-amino; or Rand Rtogether form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NRRforms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.