The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2012
Filed:
Jan. 11, 2007
William R. Jacobs, Jr., Pelham, NY (US);
Steven A. Porcelli, Bronx, NY (US);
Miriam Braunstein, Chapel Hill, NC (US);
William R. Jacobs, Jr., Pelham, NY (US);
Steven A. Porcelli, Bronx, NY (US);
Miriam Braunstein, Chapel Hill, NC (US);
Albert Einstein College of Medicine of Yeshiva University, Bronx, NY (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Abstract
Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are notor. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenicin a human using the above mycobacterial mutants.