The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2012
Filed:
Oct. 21, 2009
Ji LI, Thousand Oaks, CA (US);
Wenyan Shen, Wayne, PA (US);
Hsieng Sen LU, Westlake Village, CA (US);
William Gleason Richards, Thousand Oaks, CA (US);
Ji Li, Thousand Oaks, CA (US);
Wenyan Shen, Wayne, PA (US);
Hsieng Sen Lu, Westlake Village, CA (US);
William Gleason Richards, Thousand Oaks, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.