The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2012
Filed:
Mar. 30, 2007
Hang Zhao, Westborough, MA (US);
Stefan G. Koenig, Shrewsbury, MA (US);
Charles P. Vandenbossche, Waltham, MA (US);
Surendra Singh, Shrewsbury, MA (US);
Harold Scott Wilkinson, Westborough, MA (US);
Roger P. Bakale, Malvern, PA (US);
Hang Zhao, Westborough, MA (US);
Stefan G. Koenig, Shrewsbury, MA (US);
Charles P. Vandenbossche, Waltham, MA (US);
Surendra Singh, Shrewsbury, MA (US);
Harold Scott Wilkinson, Westborough, MA (US);
Roger P. Bakale, Malvern, PA (US);
Sunovion Pharmacuticals Inc., Marlborough, MA (US);
Abstract
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.