The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2012
Filed:
Jun. 17, 2011
Isaac S. Carrico, Stony Brook, NY (US);
Brian L. Carlson, Richmond, CA (US);
Peng Wu, Berkeley, CA (US);
Carolyn Ruth Bertozzi, Berkeley, CA (US);
Isaac S. Carrico, Stony Brook, NY (US);
Brian L. Carlson, Richmond, CA (US);
Peng Wu, Berkeley, CA (US);
Carolyn Ruth Bertozzi, Berkeley, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.