The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2012
Filed:
Oct. 10, 2011
Thomas Buelter, Denver, CO (US);
Peter Meinhold, Denver, CO (US);
Reid M. Renny Feldman, San Francisco, CA (US);
Andrew C. Hawkins, Parker, CO (US);
Jun Urano, Irvine, CA (US);
Sabine Bastian, Pasadena, CA (US);
Frances Arnold, La Canada, CA (US);
Thomas Buelter, Denver, CO (US);
Peter Meinhold, Denver, CO (US);
Reid M. Renny Feldman, San Francisco, CA (US);
Andrew C. Hawkins, Parker, CO (US);
Jun Urano, Irvine, CA (US);
Sabine Bastian, Pasadena, CA (US);
Frances Arnold, La Canada, CA (US);
Gevo, Inc., Englewood, CO (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.