The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
Jun. 05, 2006
Nicola Dioguardi, Milan, IT;
Fabio Grizzi, Milan, IT;
Carlo Russo, Corsico, IT;
Barbara Franceschini, Pogliano Milanese, IT;
Nicola Dioguardi, Milan, IT;
Fabio Grizzi, Milan, IT;
Carlo Russo, Corsico, IT;
Barbara Franceschini, Pogliano Milanese, IT;
Humanitas Mirasole S.p.A., Rozzano, IT;
Abstract
The present invention relates to an 'in vitro' diagnostic method for diseases affecting human or animal tissues, in particular for the diagnosis of diseases involving inflammation and fibrosis in human or animals, more particularly for liver diseases. More particularly, the present invention relates to a method for diagnosing 'in vitro' abnormal morphological conditions in human or animal tissues affected by a chronic inflammatory disease, which comprises observing an image of a biopsy sample of the human or animal body in which said abnormal condition can be detected and metrically quantifying said abnormal morphological condition, wherein said step of metrically quantifying comprises detecting the extent of the fibrotic and of the inflammatory tissue by means of: i) calculating the fractal corrected perimeter (Pf) and/or area (Af) of the collagen islets, and ii) calculating the percentage area of the clustered inflammatory cells by means of the formula ACINF/AB·100, wherein ACiNF is the actual area of the inflammatory cells belonging to clusters and AB is the area of the biopsy sample.