The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
Oct. 31, 2005
Alicja Bielawska, Charleston, SC (US);
Zdzislaw M. Szulc, Charleston, SC (US);
Yusuf A. Hannun, Sullivan's Island, SC (US);
Lina M. Obeid, Sullivan's Island, SC (US);
Besim Ogretmen, Mt. Pleasant, SC (US);
Alicja Bielawska, Charleston, SC (US);
Zdzislaw M. Szulc, Charleston, SC (US);
Yusuf A. Hannun, Sullivan's Island, SC (US);
Lina M. Obeid, Sullivan's Island, SC (US);
Besim Ogretmen, Mt. Pleasant, SC (US);
MUSC Foundation for Research Development, Charleston, SC (US);
Abstract
The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.