The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
Sep. 04, 2007
Jeffrey S. Glenn, Palo Alto, CA (US);
Tina Marie Myers, Indianapolis, IN (US);
John Irvin Glass, Germantown, MD (US);
Jeffrey S. Glenn, Palo Alto, CA (US);
Tina Marie Myers, Indianapolis, IN (US);
John Irvin Glass, Germantown, MD (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
An amphipathic helix at the approximate N-terminus of Hepatitis C virus (HCV) nonstructural proteins mediates the association of these proteins with cytoplasmic membranes in infected cells. This association is essential for replication. Thus, assessing the ability of compounds or protocols to disrupt the association of such helices with cytoplasmic membranes permits identification of compounds and protocols which are useful in the treatment of HCV infection. Also useful in the invention are mimics, or function-disrupting ligands, of an amphipathic helix of the nonstructural proteins described herein and antibodies and fragments thereof immunoreactive with said helix.