The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2012

Filed:

Mar. 29, 2006
Applicants:

Frank Diaz, Florence, AL (US);

Francine S. Farouz, San Diego, CA (US);

Ryan Coatsworth Holcomb, Salt Lake City, UT (US);

Edward A. Kesicki, Bothell, WA (US);

Kimba Lee Fischer, Longmont, CO (US);

Adam Wade Cook, Broomfield, CO (US);

Inventors:

Frank Diaz, Florence, AL (US);

Francine S. Farouz, San Diego, CA (US);

Ryan Coatsworth Holcomb, Salt Lake City, UT (US);

Edward A. Kesicki, Bothell, WA (US);

Kimba Lee Fischer, Longmont, CO (US);

Adam Wade Cook, Broomfield, CO (US);

Assignee:

ICOS Corporation, Indianapolis, IN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); A61K 31/497 (2006.01); A61K 31/5355 (2006.01); A61K 31/541 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.


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