The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
May. 31, 2007
Applicants:
Karyn Mcfadden, Philadelphia, PA (US);
Irwin M. Chaiken, Gladwyne, PA (US);
Inventors:
Karyn McFadden, Philadelphia, PA (US);
Irwin M. Chaiken, Gladwyne, PA (US);
Assignee:
Philadelphia Health and Education Corporation d/b/c Drexel University College of Medicine, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C07K 7/00 (2006.01); G01N 33/53 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides a recombinant multi-functional chimera of CVN and 12p1. Chimeras of CVN and 12p1 present a model for targeting gp120 at two discrete sites, by two different modes of inhibition and with increasing potency versus either component alone. A chimera of the invention combines the high affinity suppression of viral activity by CVN with the allosteric suppression of viral envelope binding to both CD4 and co-receptor by 12p1.