The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
Sep. 15, 2006
Laurence Arbibe, Paris, FR;
Philippe Sansonetti, Paris, FR;
Claude Parsot, Paris, FR;
Kim Dong Wook, Seoul, KR;
Armelle Phalipon, Paris, FR;
Laurence Arbibe, Paris, FR;
Philippe Sansonetti, Paris, FR;
Claude Parsot, Paris, FR;
Kim Dong Wook, Seoul, KR;
Armelle Phalipon, Paris, FR;
Institut Pasteur, Paris, FR;
Inserm (Institut National de la Sante et de la Recherche Medicale), Paris, FR;
Abstract
The ospF gene ofencodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain ofcontaining an inactivated ospF gene is also provided.