The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Mar. 04, 2005
Hitoshi Ikeya, Machida, JP;
Tadashi Morikawa, Machida, JP;
Koichi Takahashi, Machida, JP;
Tatsuya Tamura, Gotenba, JP;
Akira Okamachi, Susono, JP;
Takenori Ishizawa, Gotenba, JP;
Haruhiko Sato, Gotenba, JP;
Yoshinobu Higuchi, Gotenba, JP;
Hitoshi Ikeya, Machida, JP;
Tadashi Morikawa, Machida, JP;
Koichi Takahashi, Machida, JP;
Tatsuya Tamura, Gotenba, JP;
Akira Okamachi, Susono, JP;
Takenori Ishizawa, Gotenba, JP;
Haruhiko Sato, Gotenba, JP;
Yoshinobu Higuchi, Gotenba, JP;
Denki Kagaku Kogyo Kabushiki Kaisha, Tokyo, JP;
Abstract
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.