The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Mar. 16, 2009
Mary Collins, Natick, MA (US);
Clive R. Wood, Boston, MA (US);
Beatriz M. Carreno, Acton, MA (US);
Deborah Luxenberg, Melrose, MA (US);
Jason Jussif, Salem, NH (US);
Laura L. Carter, Medford, MA (US);
Frances K. Bennett, Sudbury, MA (US);
Viia Valge-archer, Little Abbington, GB;
John Andrews, Little Hadham Ware, GB;
Caroline Russell, Herts, GB;
Mary Collins, Natick, MA (US);
Clive R. Wood, Boston, MA (US);
Beatriz M. Carreno, Acton, MA (US);
Deborah Luxenberg, Melrose, MA (US);
Jason Jussif, Salem, NH (US);
Laura L. Carter, Medford, MA (US);
Frances K. Bennett, Sudbury, MA (US);
Viia Valge-Archer, Little Abbington, GB;
John Andrews, Little Hadham Ware, GB;
Caroline Russell, Herts, GB;
Wyeth, Madison, NJ (US);
MedImmune Limited, , GB;
Abstract
This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.